In 1862, Victor Hugo reportedly wrote to his publisher to ask how his newly published novel Les Misérables was selling, with a single character query: “?” The response: “!” This story of one of the ...

Nearly 25 years after scientists completed a draft human genome sequence, many of its 3.1 billion letters remain a puzzle. The 98% of the genome that is not made of protein-coding genes — but which ...

St. Jude Children’s Research Hospital scientists have identified specific DNA variants in the non-coding regions of the genome contributing to chemotherapy resistance in acute lymphoblastic leukemia ...

(L to R) Co-first author Jackson Mobley, PhD, corresponding author Daniel Savic, PhD, and co-first author Kashi Raj Bhattarai, PhD, all of the St. Jude Department of Pharmacy and Pharmaceutical ...

Non-coding DNA variants contribute to acute lymphoblastic leukemia (ALL) chemotherapy resistance. St. Jude Children's Research Hospital scientists have identified specific DNA variants in the ...

Next-generation sequencing (NGS) technologies, used to rapidly read genetic information, have consistently opened new frontiers in biology. The first NGS device – 454 Life Sciences’ Genomic Sequencer ...

The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark ...