Over the last several years the identification and functional characterization of the motor proteins actin and myosin in the nucleus has initiated a change in the view of nuclear processes. It is now ...

The Journal of Cell Biology (JCB) is a not-for-profit publication, edited by scientists, and a leading life sciences journal. The JCB publishes papers on all aspects of cellular structure and function ...

The inner cortex of eukaryotic cells is largely composed of the protein actin, organized in a filamentous network that forms the cytoskeleton. The actin cytoskeleton plays major roles in cellular ...

Cell generated force plays essential roles in a wide range of biological processes, such as cell motility, cytokinesis, and tissue morphogenesis. In a study published in Nature Communications, a ...

Some cells, such as immune cells, are highly mobile—they constantly remodel their shape, migrate toward a wound that needs to be closed or chase down bacteria in the bloodstream. This mobility is ...

Extracts of the soluble cytoplasmic proteins of the sea urchin egg form gels of different composition and properties depending on the temperature used to induce actin polymerization. At temperatures ...

Hypertrophic cardiomyopathy (HCM) is the most common hereditary heart disease. It causes the left ventricle to thicken, the ...

The Fowler laboratory studies cellular architecture: how cells spatially organize themselves and their interior compartments to achieve intricate geometries, mechanical strength, and physiological ...