Back in the good old days, so many things were easier to understand. I once disassembled the engine of my 1972 MG just to see how it worked, but now I won't touch the squirrel's nest of technology ...
You have full access to this article via your institution. Surprisingly, 'fixing' the matrices does not improve performance (see Fig. 1); the RBLOSUM64 matrix performs consistently worse than BLOSUM62 ...
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