This article introduces the field of bioinformatics and its importance as a cornerstone of biological research, as well as ...

Historical introduction and overview -- Collecting and storing sequences in the laboratory -- Alignment of pairs of sequences -- Introduction to probability and statistical analysis of sequence ...

The classic methodology of inferring a phylogenetic tree from sequence data is composed of two steps. First, a multiple sequence alignment (MSA) is computed. Then, a tree is reconstructed assuming the ...

Proteins, with their extraordinary diversity of structure and function, pose some of the toughest problems in the field of bioinformatics, giving rise to a growing arsenal of computational tools for ...