文章综述了CRISPR（Clustered Regularly Interspaced Short Palindromic Repeats）技术在CAR-T（Chimeric Antigen Receptor T-Cell Immunotherapy）疗法中的应用，通过CRISPR可以提高CAR-T疗法的安全性和有效性（图1）。
From a bacterial immune defense system to a versatile gene-editing tool, CRISPR technology has transformed genetic research by enabling precise modifications in living cells. Scientists are continuing ...
在过去的几年里，CRISPR频频被新闻报道，这是有原因的。这种工具使基因编辑变得比以往任何时候都更加容易和更快速，CRISPR在治疗疾病方面已经显示出巨大潜力，这项技术已经加速用于对各种人类疾病潜在原因的研究。此外，该技术已经开始了临床试验，将 ...
在基因编辑领域，CRISPR-Cas13 系统应用广泛却存在争议。为解决其在体内应用的局限，研究人员以斑马鱼为模型优化该技术。他们发现化学修饰的 gRNA 可增强效果，还评估了多种系统。这为优化 RNA 靶向技术及推动体内应用意义重大。 基因编辑技术的发展为生命 ...
When a neuron in our body gets damaged, segments of RNA produce proteins that can help repair the injury. But in neurological disorders such as ALS and spinal muscular atrophy, or following spinal ...
来自全球多领域的研究人员针对CRISPR-Cas9基因编辑技术的伦理风险与社会影响开展研究，系统探讨了该技术在疾病治疗（如镰状细胞贫血、囊性纤维化）、农业改良及环境适应中的突破性应用，同时警示其可能加剧基因不平等、引发优生学争议等问题。研究提出 ...
Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this ...
Clustered Regularly Interspaced Short Palindromic Repeats, or CRISPR for short forms part of a new ground-breaking gene-editing technology, known as CRISPR-Cas9. Many developments to CRISPR technology ...
When a neuron in our body gets damaged, segments of RNA produce proteins that can help repair the injury. But in neurological disorders such as ALS and spinal muscular atrophy, or following spinal ...
Genetic modifications in reproductive cells, such as eggs, sperm, or embryos, are commonly referred to as germline editing and are heritable. 1 CRISPR-Cas 9, which stands for clustered regularly ...
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