If you can't delete an ISO file as the file is open in your System, check if it is mounted as a drive or not. Uses these proven fixes to resolve the issue.

If you cannot delete a file or a folder on an NTFS file system volume in Windows, follow the solutions mentioned in this post to resolve the issue.

Fire up process explorer and find the file is in use by, wait for it, Windows explorer. So Windows Explorer can't rename/move my file because it's in use by itself.

I am in the process of cleaning up my hard drives. I'm having a problem deleting a file in my old Temp. Internet Files folder from a previous Windows installation.The file is called TILE\\1~1,JPG ...