If you receive Microsoft Excel cannot access the file, There are several possible reasons error message you can use the following suggestions to resolve the issue.

If you see The file couldn't open in protected view error while opening Microsoft Excel, the fixes listed in this post will help you.

File-security limits can curtail your ability to open or save Microsoft Excel files.

How to Open an XLS File in Excel. XLS files are Excel workbook files created in Excel 97 or Excel 2003. The 2007, 2010 and 2013 versions of the program use the XLSX format by default to save ...

Microsoft is making an important change to Excel to prevent attackers from spreading malware or phishing campaigns.