The cytoskeleton is a cellular scaffolding system whose functions include maintenance of cellular shape, enabling cellular migration, division, intracellular transport, signaling and membrane ...

Huntington’s disease is a rare genetic disorder and a representative neurodegenerative disease, characterized by loss of ...

Huntington's disease is a rare genetic disorder and a representative neurodegenerative disease, characterized by loss of ...

Coordination of microtubules and the actin cytoskeleton is important in several types of cell movement. mDia1 is a member of the formin-homology family of proteins and an effector of the small GTPase ...

SETD2, known for its involvement on gene expression, also can affect functions controlled by the cytoskeleton, such as movement, metastasis and migration, which are very important for cancer cells.

Cells grow, divide, change their shape and move. They provide structure for the body and tissues, enter wounds to close them or chase down bacteria in our blood. The mobility of cells is a ...

Actin filaments (F-actin) are key components of sarcomeres, the basic contractile units of skeletal muscle myofibrils. A crucial step during myofibril differentiation is the sequential exchange of ...

For immune cells, the actin cytoskeleton is more than a structural scaffold. Immune cells can migrate to sites of infection ...

In the 1950s, advances in microscopy techniques allowed scientists to visualize synaptic communication between two brain cells for the first time. 1,2 However, many details beyond the general synapse ...

Robert Mauck, PhD, from the University of Pennsylvania, discussed how aging and differentiation alter nuclear mechanobiology at the 2014 American Society of Bone and Mineral Research Conference in ...