Although randomization has been used in phase I trials to simultaneously test different doses of experimental anticancer agents (for example, pembrolizumab 65 (NCT01295827)), to our knowledge, it ...

We provide an explicit asymptotic method to evaluate the performance of different response-adaptive randomization procedures in clinical trials with continuous outcomes. We use this method to ...

Randomized clinical trials serve as the standard for clinical research and have contributed immensely to advances in patient care. Nevertheless, several shortcomings of randomized clinical trials ...

PurposeThe majority of randomized oncology trials are two-arm studies that test the efficacy of new therapies against a standard of care, thereby assigning a large proportion of patients to ...

This review article considers the strengths and weaknesses of randomized clinical trials that are conducted through the analysis of data gathered by health insurers.

Future progress in improving cancer therapy can be expedited by better prioritization of new treatments for phase III evaluation. Historically, phase II trials have been key components in the ...