Although randomization has been used in phase I trials to simultaneously test different doses of experimental anticancer agents (for example, pembrolizumab 65 (NCT01295827)), to our knowledge, it ...

We provide an explicit asymptotic method to evaluate the performance of different response-adaptive randomization procedures in clinical trials with continuous outcomes. We use this method to ...

Randomized clinical trials serve as the standard for clinical research and have contributed immensely to advances in patient care. Nevertheless, several shortcomings of randomized clinical trials ...

This review article considers the strengths and weaknesses of randomized clinical trials that are conducted through the analysis of data gathered by health insurers.

Both randomized controlled trials and real-world evidence can help define a treatment’s absolute value and its value relative to alternative interventions, but they do so in different ways.

PurposeThe majority of randomized oncology trials are two-arm studies that test the efficacy of new therapies against a standard of care, thereby assigning a large proportion of patients to ...