Specific glycans attached to the GnT-IVa and GnT-IVb can bind to the enzyme’s ligand-binding site, interfering with recognition and binding to the glycosylation proteins’ normal glycoprotein ...

A new study finds enhanced activity of a specific enzyme drives spinocerebellar ataxia type 14, which suggests inhibiting the enzyme may have therapeutic potential. pinocerebellar ataxias are a group ...

The directed evolution of enzymes for improved activity or substrate specificity commonly leads to a trade-off in stability. We have identified an activity–stability trade-off and a loss in unfolding ...