The choice between single-arm, historically controlled and randomized, concurrently controlled designs for phase II oncology clinical trials remains controversial. In practice, most phase II cancer ...

To improve the understanding of the appropriate design of phase II oncology clinical trials, we compared error rates in single-arm, historically controlled and randomized, concurrently controlled ...

§ The review from David Allison and his colleagues highlights that while randomized controlled trials are powerful tools for examining cause-and-effect relationships, they are not immune to errors and ...

Interpreting data from randomized trials: the Scandinavian prostatectomy study illustrates two common errors Andrew Vickers Nature Clinical Practice Urology 2, 404–405 (2005) Cite this article ...

Background: Clinical trials are commonly done without blinded outcome assessors despite the risk of bias. We wanted to evaluate the effect of nonblinded outcome assessment on estimated effects in ...

Anyone who’s read my stuff with any regularity is acutely aware of my disdain for the way many observational studies are conducted and interpreted in health and nutrition research, as well as my ...

Princess Margaret Hospital officials admit they’re “embarrassed” but stress no patients were harmed after an audit found errors in some of the data collected from 300 women in breast-cancer ...

Vaccine development can be a slow and uncertain matter—one often disparaged as ‘trial-and-error medicine.’ Is there no better way?

In this 13-week, randomized, controlled trial involving adults with insulin-treated type 2 diabetes, AID was associated with a greater reduction in glycated hemoglobin levels than CGM alone.

Closed-loop systems that automate insulin delivery may improve glycemic outcomes in patients with type 1 diabetes. In this 6-month randomized, multicenter trial, patients with type 1 diabetes were ...