In metastatic CRC, classifying p53 mutations as gain of function or non gain of function may predict sidedness dependent prognosis.

PURPOSETo examine the impact of TP53 gain-of-function (GOF) and non-GOF mutations on prognosis of advanced pancreatic ductal adenocarcinoma (PDAC) among patients with KRAS, CDKN2A, and SMAD4 ...

Non-pharmacological strategies such as exercise can improve hand function in patients with systemic sclerosis, according to data published in the International Journal of Rheumatic Diseases.