We have a GUI for one of the applications I work on that's written almost entirely in Python + PyQt. Everything voxmea said is true, for all good and all ill.

This module introduces how to develop Graphical User Interfaces (GUI) by ‘dragging and dropping’ various application parts in Python. Specifically, to accomplish this task a program called PyQt will ...

Not every programmer likes creating GUI code. Most hacker types don’t mind a command line interface, but very few ordinary users appreciate them. However, if you write command line programs i… ...

My GUI toolkit of choice is usually PyQT. If you are interested in knowing more about this topic, see Rapid GUI Programming with Python and QT by Mark Summerfield.