Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

“This is the first detailed study of how and where ORC regulates epigenetics and gene expression in human cells,” said Anindya Dutta, Ph.D., leader of the study and chair of the University of Alabama ...

Although HPVs do express some unspliced mRNAs (Figure 2), most HPV mRNAs are the products of constitutive and alternative splicing. Constitutive splicing is where every intron in the primary RNA ...

It provides a way to leap off and say, 'how can we use this information to develop new, modern switches that can be used in eukaryotic systems and mammalian systems.' “Prior to that work, the working ...

A new international study suggests that ancient viral DNA embedded in our genome, which were long dismissed as genetic "junk", may actually play powerful roles in regulating gene expression. Focusing ...

Epigenetics is the study of various heritable alterations that control gene expression without changing the DNA sequence. 1 The name epigenetics comes from the Greek prefix “epi”, which means on top ...

Institute researchers have developed a new multi-omics method enabling the profiling of multiple histone modifications and ...

Turning genes on and off is like flipping a light switch, controlling whether genes in a cell are active. When a gene is turned on, the production of proteins or other substances is promoted; when ...

In a recent paper published on aBIOTECH, the authors integrated epigenomic, transcriptomic, and 3D genomic data to ...

Scientists at City of Hope have uncovered a gene called SMOC1 that plays a surprising role in the development of type 2 ...