MIT engineers designed a control mechanism, known as DIAL, that allows them to establish a desired protein level, or set point, for any synthetic gene circuit.

Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

Polypurine hairpins are used to inhibit PCSK9 expression. When cholesterol levels in the blood rise too high, a condition known as hypercholesterolemia can develop, damaging arteries and threatening ...

Endocrine therapy typically slows cell cycle progression by reducing cyclin D1, which partners with CDK4/6 to promote cell ...

By profiling brains from healthy people aged one to 104, researchers found that mutations accumulate in some genes more than ...