The first thing you need to do is configure Windows to work well with multiple monitors. If you're running Windows 7 or ...
Got a spare PCI card laying around? Toss it in that last free slot; assuming you're running a recent version of windows, it'll pick it up, and you're good to go.
On Windows 10 and 11, you can use these steps to fix a second monitor not detected on your PC, and here's how.