You can embed a PDF file into a cell of an Excel worksheet and then use Excel's security features to lock the object. This allows you to take advantage of both technologies.

PDF Data Connector from Microsoft will help you import and use PDF data into Microsoft Excel spreadsheets. Learn how to use it.

Need to extract data from PDF files into a spreadsheet so you can analyze it? Find out how seven PDF to Excel conversion tools fared in head-to-head tests with increasingly complex data sources.