For a univariate linear model, the Box-Cox method helps to choose a response transformation to ensure the validity of a Gaussian distribution and related assumptions. The desire to extend the method ...

We propose the warped linear mixed model (WarpedLMM), a principled generalization of the standard LMM that allows to fit phenotype transformations while performing genetic analyses.

Scientists may wish to analyze correlated outcome data with constraints among the responses. For example, piecewise linear regression in a longitudinal data analysis can require use of a general ...