Surprisingly, however, two of the newly isolated drICE alleles are gain-of-function mutants in a heterozygous condition, although they are loss-of-function mutants homozygously.

In a novel study, researchers from the Icahn School of Medicine at Mount Sinai introduced LoGoFunc, an advanced computational tool that predicts pathogenic gain- and loss-of-function variants ...

Evidence that a loss of function contributes to disease in conjunction with a dominant gain-of-function effect comes from mice, where animals expressing solely polyglutamine-expanded ataxin have a ...

We need to ban some gain-of-function research on deadly viruses. We also need a better definition of what it is we're banning.

Gain-of-function allele of HPY1 coordinates source and sink to increase grain yield in rice ...

From cancer immunotherapy and antibiotics to GMO crops and pandemic surveillance, gain of function is a cornerstone of basic research.