Surprisingly, however, two of the newly isolated drICE alleles are gain-of-function mutants in a heterozygous condition, although they are loss-of-function mutants homozygously.

Evidence that a loss of function contributes to disease in conjunction with a dominant gain-of-function effect comes from mice, where animals expressing solely polyglutamine-expanded ataxin have a ...

In metastatic CRC, classifying p53 mutations as gain of function or non gain of function may predict sidedness dependent prognosis.

In a novel study, researchers from the Icahn School of Medicine at Mount Sinai introduced LoGoFunc, an advanced computational tool that predicts pathogenic gain- and loss-of-function variants ...

We need to ban some gain-of-function research on deadly viruses. We also need a better definition of what it is we're banning.

From cancer immunotherapy and antibiotics to GMO crops and pandemic surveillance, gain of function is a cornerstone of basic research.

Gain-of-function research involves giving a pathogen a new "ability" and is controversial because if a pathogen is mutated to become more infectious or deadly and then escapes from a lab, it could ...

The story so far: With the re-emergence of the lab-leak origin theory for the SARS-CoV-2 , questions are also being raised on what gain-of-function research is , and whether the benefits of ...

Secreted peptide ligands are known to play key roles in the regulation of plant growth, development, and environmental responses. However, phenotypes for surprisingly few such genes have been ...

Gain-of-function allele of HPY1 coordinates source and sink to increase grain yield in rice ...

Gain-of-Function: Loss-of-Funding The White House released an executive order declaring its intent to ‘stop dangerous gain-of-function research’. Also, the largest volcanic eruption ever observed.