Non-coding DNA variants contribute to acute lymphoblastic leukemia (ALL) chemotherapy resistance. St. Jude Children's Research Hospital scientists have identified specific DNA variants in the ...

By examining genomic variation more closely, scientists can now identify new disease connections with greater speed and accuracy. For centuries, scientists have recognized that certain illnesses can ...

EMBL researchers and collaborators have developed SDR-seq, a breakthrough single-cell technology that captures DNA and RNA ...

Scientists have long suspected connections between heredity and disease, dating back to Hippocrates, who observed certain ...

Noncoding elements in the genome, such as enhancers, silencers, and insulators, play important roles in gene expression and thus cellular behavior. Therefore, these elements may be of particular ...

The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark ...

Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania (Penn Medicine) have successfully employed an algorithm to identify ...

Much of the "junk" DNA in Drosophila shows signs of either negative or positive selection, according to a study in this week's Nature. An analysis by Peter Andolfatto of the University of California, ...

Regulatory genes -- genes that control how other genes are used -- are responsible for 69% of the heritability of dairy cattle traits such as milk production and fertility, according to a new study.

Imagine the human genome as a string stretching out for the length of a football field, with all the genes that encode proteins clustered at the end near your feet. Take two big steps forward; all the ...

(L to R) Co-first author Jackson Mobley, PhD, corresponding author Daniel Savic, PhD, and co-first author Kashi Raj Bhattarai, PhD, all of the St. Jude Department of Pharmacy and Pharmaceutical ...