Objectives We hypothesised that low flow low gradient aortic stenosis (LFLGAS) is associated with more severe coronary microvascular dysfunction (CMD) compared with normal-flow high-gradient aortic ...
Background Pridopidine is a well-tolerated, oral Sigma-1 receptor (S1R) agonist. Human PET imaging shows pridopidine 45 mg bid, the dose currently evaluated in PROOF-HD, has selective and robust S1R ...
Background Pridopidine is a safe, well-tolerated oral drug candidate, that potently activates the Sigma-1 Receptor (S1R). The S1R regulates many cellular processes.. Human brain PET studies show that ...
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