As I’m not currently in the mood of bricking my laptop by changing the default python version, I decided to install PyQt5 in a python virtual environment. Btw, Fedora 22 should have python 3 by ...

I have even tried to manually add the directory with the dlls via os.add_dll_directory(path) (this is what is happening in the __init__ file of PyQt5) in the REPL (when you omit the python_config.run_ ...