Will having python installed without some type of virtual environment effect anything that is related to the Mac OS python, specially when installing pip packages?

If the user wants to install or upgrade pip, they should be using the OS supplied package that contains pip (assuming for some reason that their OS doesn't install pip when installing Python).

Python Development Master taps new features in Python to manage a project’s packages without the overhead imposed by a virtual environment.

Take advantage of BeeWare Briefcase to make Python programs that are a snap to deploy and easy to redistribute ...

Security firm Checkmarx found that one in three software packages from PyPI contains a flaw that can lead to malicious code being automatically installed. Many software packages from the Python ...