The development of child and adolescent self-concept was examined as a function of the self-concept domain, social/developmental/educational transitions, and gender ...
We propose a sequential approach for constructing multiple-objective locally optimal designs for nonlinear models. The technique used here is a general one and we demonstrate the added benefits of ...
The customary approach to early-phase clinical trial design, where the focus is on identification of the maximum tolerated dose, is not always suitable for noncytotoxic or other targeted therapies.