New hifiasm-ONT assembly method delivers high-quality, cost-efficient near T2T assemblies using standard Oxford Nanopore Simplex reads, broadening access to comprehensive genome assemblies across ...

Compared with Levenberg Marquardt, the local and initial value sensitive algorithm, Simplex, a global algorithm, is the only robust and easy method which is irrelevant to initial input value.

OXFORD, England, April 18, 2025--A new paper, released this week on bioRxiv, introduces hifiasm-ONT, a breakthrough genome assembly algorithm that enables partially phased, near telomere-to-telomere ...

New hifiasm-ONT assembly method delivers high-quality, cost-efficient near T2T assemblies using standard Oxford Nanopore Simplex reads, broadening access to comprehensive genome assemblies across ...

Dongliang Liu, Peng Zheng, Jianghao Wu, Haotian Yin, Linna Zhang, A new method for cylindricity error evaluation based on increment-simplex algorithm, Science ...

The mission to improve the widely used simplex-method algorithm showed instead why it works so well.

NLPNMS Call nonlinear optimization by Nelder-Mead simplex method CALL NLPNMS ( rc, xr, "fun", x0 <,opt, blc, tc, par, "ptit", "nlc">); See "Nonlinear Optimization and Related Subroutines" for a ...