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In a naive execution (in comparison to a cache-oblivious execution) of such a seed-and-extend algorithm, the seed mapping locations to be compared to the read would be streamed through the cache.
A cache is a special storage space for temporary files that makes a device, browser, or app run faster and more efficiently.
NTT developed a dedicated cache random function. This contributes to the realization of a highly secure CPU that prevents data leakage due to attacks.