Comparative effectiveness of treatment strategies for urothelial cancer of the bladder (UCB) with clinical lymph node involvement (cN+). Anti-tumor activity, safety and pharmacokinetics (PK) of AGS15E ...

PHILADELPHIA -- Researchers long thought that only one strand of a double-stranded microRNA can silence genes. Though recent evidence has challenged that dogma, it's unclear what the other strand does ...

Millions of kidney patients could benefit from early detection and prevention as a result of the breakthrough made by ...

The authors provide further insight into microRNA biology, and the simplicity of anti-miR oligonucleotide drug delivery. RNA-based therapeutics hold significant potential as promising treatment ...

Phase II trial of the oral mTOR inhibitor everolimus (RAD001) for patients with relapsed or refractory lymphoma Mantle Cell Lymphoma (MCL) represents only 5–10% of all non-Hodgkins lymphomas, making ...

Researchers identified microRNA-93 as a genetic driver of fatty liver disease and showed that vitamin B3 can effectively ...

Victor Ambros, a developmental biologist at the University of Massachusetts Chan Medical School, and Gary Ruvkun, a geneticist at Harvard Medical School, won this year’s Nobel Prize in Physiology or ...

Dr. Yogesh Dwivedi authored a book chapter “microRNA Function and Dysregulation in Depression and Suicide” in Suicide Phenomenology and Neurobiology, Edited by: Keri Cannon and Thomas Hudzik.

microRNAs (miRNA), non-coding RNA molecules, are widely known for regulating mRNA stability and translation. miR-10b has been increasingly implicated in the pathogenesis of gliomas, cancers of the ...

With limited treatment options for stroke patients available, two UConn researchers are developing an experimental drug that is capable of protecting the brain and improving recovery after a cerebral ...